Magnetic Levitation of Personalized Nanoparticle-Protein Corona as an Effective Tool for Cancer Detection.

ABSTRACT: Unprecedented opportunities for early stage cancer detection have recently emerged from the characterization of the personalized protein corona (PC), i.e., the protein cloud that surrounds nanoparticles (NPs) upon exposure to a patients' bodily fluids. Most of these methods require "direct characterization" of the PC., i.e., they necessitate protein isolation, identification, and quantification. Each of these steps can introduce bias and affect reproducibility and inter-laboratory consistency of experimental data. To fulfill this gap, here we develop a nanoparticle-enabled blood (NEB) test based on the indirect characterization of the personalized PC by magnetic levitation (MagLev). The MagLev NEB test works by analyzing the levitation profiles of PC-coated graphene oxide (GO) NPs that mig

SUBMITTER: Quagliarini E 

PROVIDER: S-EPMC9104194 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature