Dataset Information

Perfluoroalkyl Substances (PFASs) in Rivers and Drinking Waters from Qingdao, China.

ABSTRACT: Perfluoroalkyl substances (PFASs) in rivers; drinking water sources (reservoirs and groundwater); and various types of drinking waters (tap waters, barreled pure waters, and bottled mineral waters) in Qingdao, Eastern China were quantified by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The total concentrations of PFASs (ΣPFASs) in the river waters ranged from 28.3 to 292.2 ng/L, averaging 108 ± 70.7 ng/L. PFBS was the most abundant compound, with a maximum concentration of 256.8 ng/L, followed by PFOA (maximum concentration: 72.4 ng/L) and PFBA (maximum concentration: 41.6 ng/L). High levels of PFASs were found in rivers in the suburban and rural areas. The estimated annual mass loading of the total PFASs to Jiaozhou Bay (JZB) was 5.9 tons. The PFASs in the drinking water reservoirs were relatively low. The ΣPFASs in the tap water ranged from 20.5 ng/L to 29.9 ng/L. Differences in the PFAS levels and composition profiles were found among barreled water at different market sites and for different brands of mineral water products. The sequence of the contamination levels of the waters related to drinking water was reservoir water > tap water > barrel water > groundwater > bottled mineral water. The PFASs in drinking water may not pose a serious risk to the drinking water consumers of Qingdao City.

SUBMITTER: Lu G

PROVIDER: S-EPMC9104605 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Perfluoroalkyl Substances (PFASs) in Rivers and Drinking Waters from Qingdao, China.

Lu Guohui G Shao Pengwei P Zheng Yu Y Yang Yongliang Y Gai Nan N

International journal of environmental research and public health 20220508 9

Perfluoroalkyl substances (PFASs) in rivers; drinking water sources (reservoirs and groundwater); and various types of drinking waters (tap waters, barreled pure waters, and bottled mineral waters) in Qingdao, Eastern China were quantified by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The total concentrations of PFASs (ΣPFASs) in the river waters ranged from 28.3 to 292.2 ng/L, averaging 108 ± 70.7 ng/L. PFBS was the most abundant compound, with a maximum conce ...[more]

PMID: 35565116

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Project description:Perfluoroalkyl and polyfluoroalkyl substances (PFASs) may have a role in impaired health. However, the data on the association between PFASs and Systemic lupus erythematosus (SLE) have been limited. We designed a population-based case-control study in China and evaluated the association. 100 normal persons (Control) and 100 SLE patients (Case) were obtained from 113 controls and 125 cases according to matching conditions. Serum samples were collected by venipuncture for UHPLC-MRM-MS Analysis to obtain the concentration of five PFASs in participants. Demographic characterization description was performed for the two groups of participants, the PFASs concentration distribution of the two groups was described and compared, then divided into three tiers (< 50th, 50th ~ 75th, > 75th) for subsequent analysis. Conditional logistic regression models were utilized to calculate the odds ratios (ORs) and 95% CIs for SLE. Relationship between changes in the concentration of PFASs and the risk of SLE assessed by restricted cubic spline. As the highest serum levels of the five PFASs tested in this study population, the highest perfluoroundecanoic acid (PFUnA) quartile had a 2.78-fold (95%CI: 1.270, 6.10) compared with the lowest quartile of PFUnA exposure, other types of PFASs also showed high association with SLE as well as PFASs mixture. Additionally, the exposure of PFASs exist a dose-response relationship (ptrend < 0.05). This risk association remained be found after adjusting the covariates in model 1 (adjustment of BMI) and in model 2(adjustment of BMI, smoking, drinking, hypertension and leukocyte). The restricted cubic spline illustrated a gradual increase in the possible risk of SLE with the increasing exposure of PFASs components levels. Our study firstly revealed that PFASs are risk factors for SLE and PFASs exposures are associated with SLE risk in a dose - response manner. Evidence from larger and more adequately powered cohort studies is needed to confirm our results.

Project description:BackgroundPerfluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Recent studies have implicated exposure to PFASs as a risk factor for breast cancer in Europe and America. Little is known about the role of PFASs with respect to breast cancer in the Chinese population.MethodsParticipants who were initially diagnosed with breast cancer at Tianjin Medical University Cancer Institute and Hospital between 2012 and 2016 were recruited as cases. The controls were randomly selected from the participants with available blood samples in the Chinese National Breast Cancer Screening Program (CNBCSP) cohort. Ultimately, we enrolled 373 breast cancer patients and 657 controls. Plasma PFASs were measured by an ultra-performance liquid chromatography (UPLC) system coupled to a 5500 Q-Trap triple quadrupole mass spectrometer. A logistic regression model with least absolute shrinkage and selection operator (LASSO) regularization was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationships between PFASs and breast cancer. The three most predictive variables in the LASSO model were selected from 17 PFASs, which was based on the optimal penalty coefficient (λ = 0.0218) identified with the minimum criterion. Additionally, Bayesian kernel machine regression (BKMR) and quantile g-computation models were applied to evaluate the associations between separate and mixed exposure to PFASs and breast cancer.ResultsPerfluorooctanesulfonic acid (PFOS) exhibited the highest concentration in both the cases and controls. Perfluorooctanoic acid (PFOA) and perfluoro-n-decanoic acid (PFDA) were positively associated with breast cancer, and perfluoro-n-tridecanoic acid (PFTrDA) was negatively associated with breast cancer according to both the continuous-PFASs and the quartile-PFASs logistic regression models. Of note, PFOA was associated with the occurrence of estrogen receptor (ER)-, progesterone receptor (PR)-, and human epidermal growth factor receptor 2 (HER2)-positive breast cancer (ORER+ = 1.47, 95% CI: 1.19, 1.80; ORPR+ = 1.36, 95% CI: 1.09, 1.69; ORHER2 = 1.62, 95% CI: 1.19, 2.21).ConclusionsOverall, we observed that PFASs were associated with breast cancer in Chinese women. Prospective cohort studies and mechanistic experiments are warranted to elucidate whether these associations are causal.

Dataset Information

Perfluoroalkyl Substances (PFASs) in Rivers and Drinking Waters from Qingdao, China.

Publications

Perfluoroalkyl Substances (PFASs) in Rivers and Drinking Waters from Qingdao, China.

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