Design, Synthesis, and Antifungal Activity of 4-Amino Coumarin Based Derivatives.

ABSTRACT: A series of 30 succinate dehydrogenase inhibitors (SDHIs) of 4-amino coumarin-based derivatives were designed and synthesized. According to the analysis of fungicidal activity in vitro, most of the compounds expressed broad-spectrum antifungal activity against four plant pathogenic fungi (Alternaria alternata, Alternaria solani, Fusarium oxysporum, and Botrytis cinerea) using the mycelium growth inhibition method. The results showed that compounds 3n with the group of 2-ene-3-methyl-butyl and 4e with the group of 2-bromo-1-oxo-hexyl displayed excellent activity against Alternaria alternata and Alternaria solani, with EC₅₀ values of 92~145 μg/mL. Molecular docking showed that the inhibitor 3n was completely locked into the cavity o

SUBMITTER: Xu L 

PROVIDER: S-EPMC9104767 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature