Immunotherapy for HER2-Positive Breast Cancer: Clinical Evidence and Future Perspectives.

ABSTRACT: Breast cancer is the most common malignancy among women worldwide, and HER2-positive breast cancer accounts for approximately 15% of all breast cancer diagnoses. The advent of HER2-targeting therapies has dramatically improved the survival of these patients, significantly reducing their risk of recurrence and death. However, as a significant proportion of patients ultimately develop resistance to these therapies, it is extremely important to identify new treatments to further improve their clinical outcomes. Immunotherapy has revolutionized the treatment and history of several cancer types, and it has already been approved as a standard of care for patients with triple-negative breast cancer. Based on a strong preclinical rationale, immunotherapy in HER2-positive breast cancer represents a

SUBMITTER: Agostinetto E 

PROVIDER: S-EPMC9105460 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature