Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties.

ABSTRACT: Electrospun cellulose nanofiber nonwovens have shown promise in wound dressing owing to the highly interconnected pore structure, high hydrophilicity coupled with other coveted characteristics of biodegradability, biocompatibility and renewability. However, electrospun cellulose wound dressings with loaded drugs for better wound healing have been rarely reported. In this study, a novel wound dressing with a high drug loading capacity and sustained drug release properties was successfully fabricated via electropinning of cellulose followed by polyethylenimine (PEI)-functionalization. Remarkably, the grafted PEI chains on the surface of electrospun cellulose nanofibers provided numerous active amino groups, while the highly porous structure of nonwovens could be well retained after modificat

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9105497 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature