Testing for rare genetic causes of obesity: findings and experiences from a pediatric weight management program.

ABSTRACT:

Background

Genetic screening for youth with obesity in the absence of syndromic findings has not been part of obesity management. For children with early onset obesity, genetic screening is recommended for those having clinical features of genetic obesity syndromes (including hyperphagia).

Objectives

The overarching goal of this work is to report the findings and experiences from one pediatric weight management program that implemented targeted sequencing analysis for genes known to cause rare genetic disorders of obesity.

Subjects/methods

This exploratory study evaluated youth tested over an 18-month period using a panel of 40-genes in the melanocortin 4 receptor pathway. Medical records were reviewed for demographic and visit information, including body mass index (

SUBMITTER: Roberts KJ 

PROVIDER: S-EPMC9105591 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature