Systematic Review and Metaanalysis of Worldwide Incidence and Prevalence of Antineutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis.

ABSTRACT:

Objective

In this study, we aimed to evaluate the worldwide incidence and prevalence of ANCA-associated vasculitis (AAV).

Methods

A systematic search of Medline and Embase was conducted until June 2020 for studies that analyzed the incidence and prevalence of patients aged >16 years diagnosed with AAV in different geographical areas. A meta-analysis was undertaken to estimate the pooled incidence per million person-years and prevalence per million persons in AAV overall and for each subtype of AAV: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). The 95% confidence interval (CI) and I² for heterogeneity were calculated.

Results

The meta-analysis included 25 studies that met

SUBMITTER: Redondo-Rodriguez R 

PROVIDER: S-EPMC9106044 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature