Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex.

ABSTRACT: Three large-scale networks are considered essential to cognitive flexibility: the ventral and dorsal attention (VANet and DANet) and salience (SNet) networks. The ventrolateral prefrontal cortex (vlPFC) is a known component of the VANet and DANet, but there is a gap in the current knowledge regarding its involvement in the SNet. Herein, we used a translational and multimodal approach to demonstrate the existence of a SNet node within the vlPFC. First, we used tract-tracing methods in non-human primates (NHP) to quantify the anatomical connectivity strength between different vlPFC areas and the frontal and insular cortices. The strongest connections were with the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) - the main cortical SNet nodes. These inputs converged in the ca

SUBMITTER: Trambaiolli LR 

PROVIDER: S-EPMC9106333 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature