Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1.

ABSTRACT:

Background

Sodium thiosulfate (STS) is a recognized drug with antioxidant and H₂S releasing properties. We recently showed that STS attenuated organ dysfunction and injury during resuscitation from trauma-and-hemorrhage in CSE-ko mice, confirming its previously described organ-protective and anti-inflammatory properties. The role of H₂S in diabetes mellitus type 1 (DMT1) is controversial: genetic DMT1 impairs H₂S biosynthesis, which has been referred to contribute to endothelial dysfunction and cardiomyopathy. In contrast, development and severity of hyperglycemia in streptozotocin(STZ)-induced DMT1 was attenuated in CSE-ko mice. Therefore, we tested the hypothesis whether STS would also exert organ-protective effects in CSE-ko mice with STZ-induced

SUBMITTER: Groger M 

PROVIDER: S-EPMC9106371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature