Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.

ABSTRACT:

Background

Aging is a major risk factor for a range of chronic diseases. Oxidative stress theory of aging has been previously proposed as one of the mechanisms responsible for the age-related decline in organ/tissue function and the development of age-related diseases. Urine contains rich biological information on the health status of every major organ system and can be an important noninvasive source for biomarkers of systemic oxidative stress in aging.

Aims

The objective of this cross-sectional study was to validate a novel panel of urinary oxidative stress biomarkers.

Methods

Nucleic acid oxidation adducts and oxidative damage markers of lipids and proteins were assessed in urine samples from nondiabetic and currently nonsmoking subjects (n = 198) across dif

SUBMITTER: Mukli P 

PROVIDER: S-EPMC9106456 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature