RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m⁶A-YTHDF2-dependent manner.

ABSTRACT: RNA N6-methyladenosine (m⁶A) is an emerging regulator of mRNA modifications and represents a novel player in tumorigenesis. Although it has functional significance in both pathological and physiological processes, the role of m⁶A modification in pancreatic ductal cancer (PDAC) remains elusive. Here, we showed that high fat mass and obesity-associated gene (FTO) expression was associated with a poor prognosis in PDAC patients and that suppression of FTO expression inhibited cell proliferation. Here, m⁶A sequencing (m⁶A-seq) was performed to screen genes targeted by FTO. The effects of FTO stimulation on the biological characteristics of pancreatic cancer cells, including proliferation and colony formation, were investigated in vitro and in vivo. T

SUBMITTER: Tan Z 

PROVIDER: S-EPMC9106577 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature