Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS.

ABSTRACT: The folded mitochondria inner membrane-cristae is the structural foundation for oxidative phosphorylation (OXPHOS) and energy production. By mechanically simulating mitochondria morphogenesis, we speculate that efficient sculpting of the cristae is organelle non-autonomous. It has long been inferred that folding requires buckling in living systems. However, the tethering force for cristae formation and regulation has not been identified. Combining electron tomography, proteomics strategies, super resolution live cell imaging and mathematical modeling, we reveal that the mitochondria localized actin motor-myosin 19 (Myo19) is critical for maintaining cristae structure, by associating with the SAM-MICOS super complex. We discover that depletion of Myo19 or disruption of its motor activity le

SUBMITTER: Shi P 

PROVIDER: S-EPMC9106661 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature