Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from SPRINT study.

ABSTRACT:

Background

To examine the effect of intensive blood pressure control on the occurrence of subtypes of mild cognitive impairment (MCI) and determine the risk of progression to dementia or death.

Methods

Secondary analysis of a randomized trial of community-dwelling adults (≥50 years) with hypertension. Participants were randomized to a systolic blood pressure (SBP) goal of <120 mm Hg (intensive treatment; n = 4678) or <140 mm Hg (Standard treatment; n = 4683). Outcomes included adjudicated MCI, MCI subtype (amnestic, non-amnestic, multi-domain, single domain), and probable dementia. Multistate survival models were used to examine transitions in cognitive status accounting for the competing risk of death.

Results

Among 9361 randomized participants (mean age, 67.9 years;

SUBMITTER: Gaussoin SA 

PROVIDER: S-EPMC9106821 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature