LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation.
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ABSTRACT:
SUBMITTER: Guy C
PROVIDER: S-EPMC9106921 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation.
Guy Clifford C Mitrea Diana M DM Chou Po-Chien PC Temirov Jamshid J Vignali Kate M KM Liu Xueyan X Zhang Hui H Kriwacki Richard R Bruchez Marcel P MP Watkins Simon C SC Workman Creg J CJ Vignali Dario A A DAA
Nature immunology 20220418 5
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function remains unclear. Here, we show that LAG3 moved to the immunological synapse and associated with the T cell receptor (TCR)-CD3 complex in CD4<sup>+</sup> and CD8<sup>+</sup> T cells, in the absence of binding to major histocompatibility complex class II-its canonical ligand. Mechanistically, a phylogenetically ...[more]
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