Better survival of patients with oligo- compared with polymetastatic cancers:  a systematic review and meta-analysis of 173 studies.

ABSTRACT: Background: The modern concept of oligometastatic (OM) state has been initially developed to describe patients with a low burden of disease and with a potential for cure with local ablative treatments. We systematically assessed the risk of death and relapse of oligometastatic (OM) cancers compared to cancers with more diffuse metastatic spread, through a meta-analysis of published data.  Methods: PubMed, the Cochrane Library, and EMBASE were searched for studies reporting prognosis of patients with OM solid tumors. Risk of death and relapse were extracted and pooled to provide an adjusted hazard ratio with a 95% confidence interval (HR 95%CI).  The primary outcome of the study refers to overall mortality in OM vs. polymetastatic (PM) patients.  Results. Mortality and

SUBMITTER: Petrelli F 

PROVIDER: S-EPMC9106994 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature