Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage.

ABSTRACT:

Background

The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health.

Objective

In this study, we performed the comprehensive analysis of the T cell receptor (TCR) repertoire may contribute to a more in-depth understanding of the pathogenesis of COVID-19.

Methods

A comprehensive immunological analysis was performed to explore the features of the TCR repertoire and identified TCR sequences correlated with SARS-CoV-2 viral antigens.

Results

we analyzed the COVID-19 patients' TCR repertoires in peripheral blood mononuclear cells (PBMC) which obtained before (baseline), during (acute), and after rehabilitation (convalescent)

SUBMITTER: Wang G 

PROVIDER: S-EPMC9107015 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature