Diabetes risk loci-associated pathways are shared across metabolic tissues.

ABSTRACT:

Aims/hypothesis

Numerous genome-wide association studies have been performed to understand the influence of genetic variation on type 2 diabetes etiology. Many identified risk variants are located in non-coding and intergenic regions, which complicates understanding of how genes and their downstream pathways are influenced. An integrative data approach will help to understand the mechanism and consequences of identified risk variants.

Methods

In the current study we use our previously developed method CONQUER to overlap 403 type 2 diabetes risk variants with regulatory, expression and protein data to identify tissue-shared disease-relevant mechanisms.

Results

One SNP rs474513 was found to be an expression-, protein- and metabolite QTL. Rs474513 influenced LPA mRNA and

SUBMITTER: Bouland GA 

PROVIDER: S-EPMC9107144 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature