Dataset Information

Associations of Coexisting Pain and Fatigue Severity with Physical Performance and Quality of Life Among Middle-Aged and Older Individuals with Chronic Knee Pain: Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Objective

To examine associations of combined pain and fatigue severity with physical performance and quality of life in people with chronic knee pain.

Design

Cross-sectional.

Setting

General community.

Participants

Adults (N = 193) ≥50 years of age with chronic knee pain.

Methods

Physical performance measures included the Six-Minute Walk test, Timed Up and Go test, and 20-foot timed walk test. Quality of life (QOL) was measured by the Medical Outcomes Study Short Form-12 Health Survey. The Brief Pain Inventory (BPI) and Brief Fatigue Inventory (BFI) were used to evaluate pain and fatigue. Multiple linear regression analyses were conducted to examine associations of coexisting pain and fatigue severity with physical performance and QOL.

Results

Participants were categorized by BPI and BFI scores into four severity groups: mild pain / mild fatigue; moderate pain / mild fatigue; mild pain / moderate fatigue; and moderate pain / moderate fatigue (which included severe pain / severe fatigue). The moderate pain / moderate fatigue group had significantly worse physical performance on the Six-Minute Walk (standardized beta [β] = -0.22, 95% confidence interval [CI] -0.38 to -0.06, P < 0.05) and poorer physical (β = -0.41, 95% CI -0.61 to -0.20, P < 0.001) and mental QOL (β = -0.26, 95% CI -0.46 to -0.07, P < 0.05) than the mild pain / mild fatigue group. Moreover, the mild pain / moderate fatigue group had significantly lower levels of mental QOL (β = -0.27, 95% CI -0.44 to -0.10, P < 0.05) than those of the mild pain / mild fatigue group. The moderate pain / mild fatigue group did not differ statistically from the mild pain / mild fatigue group.

Conclusions

Coexisting moderate pain and moderate fatigue were related to worse physical performance and QOL. Fatigue contributed to lower levels of mental QOL. Clinical assessment of fatigue in addition to pain should be included as a standard examination for chronic knee pain.

SUBMITTER: Chen YT

PROVIDER: S-EPMC9107156 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of Coexisting Pain and Fatigue Severity with Physical Performance and Quality of Life Among Middle-Aged and Older Individuals with Chronic Knee Pain: Secondary Analysis of a Randomized Clinical Trial.

Chen Yen Tzu YT Murphy Susan Lynn SL

Pain medicine (Malden, Mass.) 20211101 11

<h4>Objective</h4>To examine associations of combined pain and fatigue severity with physical performance and quality of life in people with chronic knee pain.<h4>Design</h4>Cross-sectional.<h4>Setting</h4>General community.<h4>Participants</h4>Adults (N = 193) ≥50 years of age with chronic knee pain.<h4>Methods</h4>Physical performance measures included the Six-Minute Walk test, Timed Up and Go test, and 20-foot timed walk test. Quality of life (QOL) was measured by the Medical Outcomes Study S ...[more]

PMID: 33772557

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Project description:ObjectiveMetabolic factors have been shown to be associated to severe radiographic knee osteoarthritis (RKOA). However, more knowledge is needed in early clinical knee osteoarthritis (KOA). The aim was to study associations between metabolic factors and radiographic knee osteoarthritis (OA) in individuals with knee pain. A second aim was to study associations between metabolic factors and RKOA in those with normal BMI and in those overweight/obese, respectively.MethodThis cross-sectional study included 282 individuals with knee pain (without cruciate ligament injury) and aged 30-67 years, and 70% women. Waist circumference, body mass index (BMI), proportion of fat and visceral fat area (VFA) were assessed. RKOA was defined as Ahlbäck grade 1 in at least one knee. Fasting blood samples were taken and triglycerides, cholesterol (total, low density lipoprotein (LDL) and high density lipoprotein (HDL)), C-reactive protein (CRP), glucose, HbA1C were analysed. Metabolic syndrome was defined in accordance with the International Diabetes Federation (IDF). Associations were analysed by logistic regression.ResultsIndividuals with RKOA were older, had higher BMI, higher VFA, larger waist circumference and had increased total cholesterol, triglycerides and LDL-cholesterol, but not fasting glucose. There was no difference between the group with RKOA vs. non-radiographic group regarding the presence of metabolic syndrome. In a subgroup analysis of individuals with normal BMI (n = 126), those with RKOA had higher VFA, more central obesity, higher levels of CRP and total cholesterol, compared with individuals without RKOA. In individuals with obesity, age was the only outcome associated to RKOA.ConclusionThere were clear associations between metabolic factors and RKOA in individuals with knee pain, also in those with normal BMI. In individuals with obesity age was the only variable associated to RKOA.Trial registrationclinicalTrials.gov Identifier: NCT04928170.

Dataset Information

Associations of Coexisting Pain and Fatigue Severity with Physical Performance and Quality of Life Among Middle-Aged and Older Individuals with Chronic Knee Pain: Secondary Analysis of a Randomized Clinical Trial.

Objective

Design

Setting

Participants

Methods

Results

Conclusions

Publications

Associations of Coexisting Pain and Fatigue Severity with Physical Performance and Quality of Life Among Middle-Aged and Older Individuals with Chronic Knee Pain: Secondary Analysis of a Randomized Clinical Trial.

Similar Datasets

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