Increased frequency of IgD-CD27^hiCD38^hi B cells and its association with the renal involvement in ANCA-associated vasculitis.

ABSTRACT:

Background

B cells have been highlighted in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the identification of activated B cells in granulomatous lesions and the efficacy of B cell depletion in treatment of AAV patients in the current study; we aimed to investigate the frequency of a specific B cell subset, IgD-CD27^hiCD38^hi B cells in AAV patients, and its association with the disease severity of AAV.

Methods

Blood samples of patients with AAV in active stage and in remission were collected. The frequency of IgD-CD27^hiCD38^hi B cells was detected by flow cytometry, and its correlation with clinicopathological parameters was analyzed.

Results

Our results showed a significant inc

SUBMITTER: Wang C 

PROVIDER: S-EPMC9107193 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature