Genomic profiling of sporadic multiple meningiomas.

ABSTRACT:

Background

Multiple meningiomas (MMs) rarely occur sporadically. It is unclear whether each individual tumor in a single patient behaves similarly. Moreover, the molecular mechanisms underlying the formation of sporadic MMs and clonal formation etiology of these tumors are poorly understood.

Methods

Patients with spatially separated MMs without prior radiation exposure or a family history who underwent surgical resection of at least two meningiomas were included. Unbiased, comprehensive next generation sequencing was performed, and relevant clinical data was analyzed.

Results

Fifteen meningiomas and one dural specimen from six patients were included. The majority of tumors (12/15) were WHO Grade I; one patient had bilateral MMs, one of which was Grade II, while the ot

SUBMITTER: Erson-Omay EZ 

PROVIDER: S-EPMC9107270 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature