Systemic quinolones and risk of retinal detachment III: a nested case-control study using a US electronic health records database.

ABSTRACT:

Background

Quinolones are popular antibiotics that are known for their potency, broad coverage, and reasonable safety. Concerns have been raised about a possible association between quinolones and retinal detachment (RD).

Methods

We conducted a nested case-control study using electronic health records (EHR) from the Health Facts® Database. The initial cohort included all patients who were admitted between 2000 and 2016, with no history of eye disease, and had a minimum medical history of one year. Eligible cases comprised inpatients who were first admitted with a primary diagnosis of RD between 2010 and 2015. Each eligible case was matched without replacement to five unique controls by sex, race, age, and period-at-risk. We used conditional logistic regression to calculate R

SUBMITTER: Taher MK 

PROVIDER: S-EPMC9107393 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature