Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

ABSTRACT: Intracellular accumulation of abnormal proteins with conformational changes is the defining neuropathological feature of neurodegenerative diseases. The pathogenic proteins that accumulate in patients' brains adopt an amyloid-like fibrous structure and exhibit various ultrastructural features. The biochemical analysis of pathogenic proteins in sarkosyl-insoluble fractions extracted from patients' brains also shows disease-specific features. Intriguingly, these ultrastructural and biochemical features are common within the same disease group. These differences among the pathogenic proteins extracted from patients' brains have important implications for definitive diagnosis of the disease, and also suggest the existence of pathogenic protein strains that contribute to the heterogeneity of pa

SUBMITTER: Tarutani A 

PROVIDER: S-EPMC9107452 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature