Circulating miRNAs in extracellular vesicles related to treatment response in patients with idiopathic membranous nephropathy.

ABSTRACT:

Background

Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only for discriminating idiopathic membranous nephropathy (IMN) from idiopathic nephrotic syndrome (INS), but also to predict the treatment response of patients with IMN.

Methods

We prospectively enrolled 60 participants, including those with IMN (n = 19) and INS (n = 21) and healthy volunteers (HVs; n = 20) in this study. Using RNA sequencing, we assessed the serum EV-miRNA profiles of all participants. To identify the EV-miRNAs predictive of treatment response in IMN, we also analyzed EV-miRNAs among patients with IMN with and without clinical remission.

Results

The expression levels of

SUBMITTER: Sun IO 

PROVIDER: S-EPMC9107687 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature