Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array.

ABSTRACT:

Background

Sex differences are known to play a role in disease aetiology, progression and outcome. Previous studies have revealed autosomal epigenetic differences between males and females in some tissues, including differences in DNA methylation patterns. Here, we report for the first time an analysis of autosomal sex differences in DNAme using the Illumina EPIC array in human whole blood by performing a discovery (n = 1171) and validation (n = 2471) analysis.

Results

We identified and validated 396 sex-associated differentially methylated CpG sites (saDMPs) with the majority found to be female-biased CpGs (74%). These saDMP's are enriched in CpG islands and CpG shores and located preferentially at 5'UTRs, 3'UTRs and enhancers. Additionally, we identified 266 significant se

SUBMITTER: Grant OA 

PROVIDER: S-EPMC9107695 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature