Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model.

ABSTRACT: The movement of fluid into, through, and out of the brain plays an important role in clearing metabolic waste. However, there is controversy regarding the mechanisms driving fluid movement in the fluid-filled paravascular spaces (PVS), and whether the movement of metabolic waste in the brain extracellular space (ECS) is primarily driven by diffusion or convection. The dilation of penetrating arterioles in the brain in response to increases in neural activity (neurovascular coupling) is an attractive candidate for driving fluid circulation, as it drives deformation of the brain tissue and of the PVS around arteries, resulting in fluid movement. We simulated the effects of vasodilation on fluid movement into and out of the brain ECS using a novel poroelastic model of brain tissue. We found t

SUBMITTER: Kedarasetti RT 

PROVIDER: S-EPMC9107702 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature