A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin.

ABSTRACT:

Background

Chemodynamic therapy (CDT) relying on intracellular iron ions and H₂O₂ is a promising therapeutic strategy due to its tumor selectivity, which is limited by the not enough metal ions or H₂O₂ supply of tumor microenvironment. Herein, we presented an efficient CDT strategy based on Chinese herbal monomer-dihydroartemisinin (DHA) as a substitute for the H₂O₂ and recruiter of iron ions to amplify greatly the reactive oxygen species (ROS) generation for synergetic CDT-ferroptosis therapy.

Results

The DHA@MIL-101 nanoreactor was prepared and characterized firstly. This nanoreactor degraded under the acid tumor microenvironment, thereby releasing DHA and iron ions. Subsequent experiments demonstrated DHA@M

SUBMITTER: Yang XX 

PROVIDER: S-EPMC9107746 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature