The sham effect of invasive interventions in chronic coronary syndromes: a systematic review and meta-analysis.

ABSTRACT:

Background

Some patients with chronic coronary syndromes undergo invasive procedures but the efficacy of such interventions remains to be robustly established by randomised sham-controlled trials (RCTs).

Purpose

To determine the sham effect in patients with chronic coronary syndromes enrolled in RCTs by performing a systematic review and meta-analysis.

Methods

In April 2022, we performed a literature search for published patient-blind RCTs (CENTRAL, MEDLINE®, PsycINFO, and reference lists) with sham procedures, reporting the pre-post effects in the invasive sham arm among patients with Canadian cardiovascular society (CCS) angina or angina equivalents.

Results

16 RCTs were included with 546 patients in the sham arm. Pooled results showed that sham interventions

SUBMITTER: Palma C 

PROVIDER: S-EPMC9107755 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature