Brain simulation augments machine-learning-based classification of dementia.

ABSTRACT:

Introduction

Computational brain network modeling using The Virtual Brain (TVB) simulation platform acts synergistically with machine learning (ML) and multi-modal neuroimaging to reveal mechanisms and improve diagnostics in Alzheimer's disease (AD).

Methods

We enhance large-scale whole-brain simulation in TVB with a cause-and-effect model linking local amyloid beta (Aβ) positron emission tomography (PET) with altered excitability. We use PET and magnetic resonance imaging (MRI) data from 33 participants of the Alzheimer's Disease Neuroimaging Initiative (ADNI3) combined with frequency compositions of TVB-simulated local field potentials (LFP) for ML classification.

Results

The combination of empirical neuroimaging features and simulated LFPs significantly outperforme

SUBMITTER: Triebkorn P 

PROVIDER: S-EPMC9107774 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature