Iron: The cancer connection.
Ontology highlight
ABSTRACT:
SUBMITTER: Torti SV
PROVIDER: S-EPMC9107937 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Iron: The cancer connection.
Torti Suzy V SV Torti Frank M FM
Molecular aspects of medicine 20200425
Iron plays an essential role in normal biological processes: The generation of cellular energy, oxygen transport, DNA synthesis and repair are all processes that require iron-coordinated proteins, either as elemental iron, heme or iron-sulfur clusters. As a transition metal with two major biological oxidation states, iron is also a critical intermediate in the generation of reactive oxygen species that can damage cellular structures and contribute to both aging and cancer. In this review, we foc ...[more]
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