Humoral Response to BNT162b2 Vaccine Against SARS-CoV-2 Variants Decays After Six Months.

ABSTRACT: SARS-CoV-2 vaccines have shown very high effectiveness in real-world scenarios. However, there is compelling evidence for a fast-paced waning of immunity. The increasing number of new variants that could alter the severity, transmissibility, and potential to evade the immune response raised significant concern. Therefore, elucidating changes in the humoral immune response against viral variants induced by vaccines over time is crucial for improving immunization protocols. We carried out a 6-month longitudinal prospective study in which 60 individuals between 21 and 71 years of age who have received the complete scheme of the BNT162b2 vaccine were followed to determine titers of serum neutralizing activity. The neutralizing capacity was measured at one, three, and six-months post-vaccinatio

SUBMITTER: Lopera TJ 

PROVIDER: S-EPMC9108166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature