Brain Functional Alteration at Different Stages of Neuropathic Pain With Allodynia and Emotional Disorders.

ABSTRACT: Neuropathic pain (NeuP), a challenging medical condition, has been suggested by neuroimaging studies to be associated with abnormalities of neural activities in some brain regions. However, aberrancies in brain functional alterations underlying the sensory-discriminative abnormalities and negative emotions in the setting of NeuP remain unexplored. Here, we aimed to investigate the functional alterations in neural activity relevant to pain as well as pain-related depressive-like and anxiety-like behaviors in NeuP by combining amplitude of low frequency fluctuation (ALFF) and degree centrality (DC) analyses methods based on resting-state functional magnetic resonance imaging (rs-fMRI). A rat model of NeuP was established via chronic constriction injury (CCI) of the sciatic nerve. Resu

SUBMITTER: Zhang YN 

PROVIDER: S-EPMC9108233 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature