Blood biomarkers in early bacterial infection and sepsis diagnostics in feverish young children.

ABSTRACT:

Background and objectives

While most feverish children have self-limiting diseases, 5-10% develop a serious and potentially life-threatening bacterial infection (BI). Due to potential risk, prompt recognition of BI and sepsis in the pediatric emergency department (PED) remains a clinical priority. The aim of the study was to evaluate the role of certain cytokines and chemokines separately and in combination with routine blood tests in early BI and sepsis diagnostics at PED.

Materials and methods

We prospectively studied children younger than 5 presenting to the PED with fever lasting for under 12 hours with high risk for serious illness. Clinical data, routine blood analysis, and inflammatory cytokine and chemokine panels were evaluated for their diagnostic abilities. Two se

SUBMITTER: Dagys A 

PROVIDER: S-EPMC9108404 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature