In Vivo Characterization of a Red Light-Activated Vasodilation: A Photobiomodulation Study.

ABSTRACT: Nitric oxide dependent vasodilation is an effective mechanism for restoring blood flow to ischemic tissues. Previously, we established an ex vivo murine model whereby red light (670 nm) facilitates vasodilation via an endothelium derived vasoactive species which contains a functional group that can be reduced to nitric oxide. In the present study we investigated this vasodilator in vivo by measuring blood flow with Laser Doppler Perfusion imaging in mice. The vasodilatory nitric oxide precursor was analyzed in plasma and muscle with triiodide-dependent chemiluminescence. First, a 5-10 min irradiation of a 3 cm² area in the hind limb at 670 nm (50 mW/cm²) produced optimal vasodilation. The nitric oxide precursor in the irradiated quadriceps tissue

SUBMITTER: Keszler A 

PROVIDER: S-EPMC9108481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature