Prevalence of Prodromal Symptoms of Parkinson's Disease in the Late Middle-Aged Population.

ABSTRACT:

Background

The prodromal phase of Parkinson's disease (PD) can last up to 20 years and is characterized by a variety of non-motor symptoms.

Objective

To determine the prevalence of a selection of non-motor symptoms known to be associated with an increased risk of developing PD in a late middle-aged population-based sample and to determine their association with motor function.

Methods

At a mean age of 60.3 years, 775 subjects were recruited from the Longitudinal Aging Study Amsterdam (LASA). Hyposmia, cognitive impairment, patient-reported constipation, possible REM-sleep behavior disorder, depression, and anxiety were indexed as known PD risk factors. Additionally, 1) the PD screening questionnaire, 2) four physical performance tests, and 3) a functional limitations

SUBMITTER: Roos DS 

PROVIDER: S-EPMC9108586 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature