Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy.

ABSTRACT: Long-term antiretroviral therapy (ART) in people living with HIV (PLHIV) is associated with sustained increases in CD4⁺ T-cell count, but its effect on the peripheral blood T-cell repertoire has not been comprehensively evaluated. In this study, we performed serial profiling of the composition and diversity of the T-cell receptor β-chain (TRB) repertoire in 30 adults with HIV infection before and after the initiation of ART to define its long-term impact on the TRB repertoire. Serially acquired blood samples from 30 adults with HIV infection collected over a mean of 6 years (range, 1-12) years, with 1-4 samples collected before and 2-8 samples collected after the initiation of ART, were available for analysis. TRB repertoires were characterized via hi

SUBMITTER: Towlerton AMH 

PROVIDER: S-EPMC9108698 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature