Monocytes are the main source of STING-mediated IFN-α production.

ABSTRACT:

Background

Type I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infection, in response to Toll-like receptor 7 (TLR7) stimulation and is more vigorous in females than in males. Whether this sex bias persists in ageing people is currently unknown. In this study, we investigated the effect of sex and aging on IFN-α production induced by PRR agonist ligands.

Methods

In a large cohort of individuals from 19 to 97 years old, we measured the production of IFN-α and inflammatory cytokines in whole-blood upon stimulation with either R-848, ODN M362 CpG-C, or cGAMP, which activate the TLR7/8, TLR9 or STING pathways, respectively. We further characterized the cellular sources of IFN-α.

Findings

We observed a female predominance in IFN-

SUBMITTER: Congy-Jolivet N 

PROVIDER: S-EPMC9108881 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature