Depression explains the association between pain intensity and pain interference among adults with neurofibromatosis.

ABSTRACT:

Introduction

Neurofibromatoses (NFs; NF1, NF2 and Schwannomatosis) are incurable genetic syndromes characterized by nerve sheath tumors and often accompanied by substantial emotional distress (e.g., depression and anxiety). Pain is also common but understudied in adults with NF and interferes with daily living. In other medical populations, depression and anxiety have a strong association with pain interference. However, research has not explored the relationship of depression and anxiety to pain interference among adults with NF experiencing pain. The aim of this study was to test the hypothesis that depression and anxiety will mediate the association between pain intensity and pain interference among geographically diverse adults with NF who endorse pain.

Methods

We used b

SUBMITTER: Doorley JD 

PROVIDER: S-EPMC9108944 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature