Management of asymptomatic severe aortic stenosis: a systematic review and meta-analysis.

ABSTRACT:

Objectives

The management of severe aortic stenosis mandates consideration of aortic valve intervention for symptomatic patients. However, for asymptomatic patients with severe aortic stenosis, recent randomised trials supported earlier intervention. We conducted a systematic review and meta-analysis to evaluate all the available data comparing the two management strategies.

Methods

PubMed, Cochrane and Web of Science databases were systematically searched from inception until 10 January 2022. The search key terms were 'asymptomatic', 'severe aortic stenosis' and 'intervention'.

Results

Meta-analysis of two published randomised trials, AVATAR and RECOVERY, included 302 patients and showed that early intervention resulted in 55% reduction in all-cause mortality (HR=0.4

SUBMITTER: Tsampasian V 

PROVIDER: S-EPMC9109115 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature