Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components.

ABSTRACT: Nanoscale ultrasound contrast agents, or nanobubbles, are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in cancer. These sub-micron particles are approximately 10x smaller than clinically available microbubbles. This allows them to effectively traverse compromised physiological barriers and circulate for extended periods of time. While various aspects of nanobubble behavior have been previously examined, their behavior in human whole blood has not yet been explored. Accordingly, herein we examined, for the first time, the short and long-term effects of blood components on nanobubble acoustic response. We observed differences in the kinetics of backscatter from nanobubble suspensions in whole blood compared to bubbles in phosp

SUBMITTER: Cooley MB 

PROVIDER: S-EPMC9109121 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature