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Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair.

ABSTRACT: Over 300 billion of cells die every day in the human body, producing a large number of endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell transplantation, a commonly used therapeutic approach in current clinical practice, generates exogenous apoEVs. It is well known that phagocytic cells engulf and digest apoEVs to maintain the body's homeostasis. In this study, we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles. Mechanistically, apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern. The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension, which is associated with the mechanical force-regulated expression of DKK1 in circulation. Furthermore, we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells. This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders.

SUBMITTER: Ma L

PROVIDER: S-EPMC9109130 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair.

Ma Lan L Chen Chider C Liu Dawei D Huang Zhiqing Z Li Jiaqi J Liu Haixiang H Kin Kwok Ryan Tsz RT Tang Benzhong B Sui Bingdong B Zhang Xiao X Tang Jianxia J Mao Xueli X Huang Weiying W Shi Songtao S Kou Xiaoxing X

Bioactive materials 20220511

Over 300 billion of cells die every day in the human body, producing a large number of endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell transplantation, a commonly used therapeutic approach in current clinical practice, generates exogenous apoEVs. It is well known that phagocytic cells engulf and digest apoEVs to maintain the body's homeostasis. In this study, we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles. M ...[more]

PMID: 35600968

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Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair.

Publications

Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair.

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