FollowTheSutures: Piloting a new way to administer onabotulinumtoxinA for chronic migraine.

ABSTRACT:

Background

Anatomical and experimental data indicate that onabotulinimtoxin A could be more efficient and cost-effective for treating chronic migraine with injections targeting the cranial sutures, where collaterals from the meninges penetrate the skull.

Methods

A new injection paradigm (FollowTheSutures) was tested for safety, tolerability and feasibility in a Phase II, open-label, non-controlled, single-center pilot study. Ninety units of onabotulinimtoxin A (Botox®), were injected in 18 sites over the area of the cranial sutures. Adverse events and potential beneficial effects were recorded in a headache diary at least 4 weeks before, and for 12 weeks after the injections. A higher dilution than normal of onabotulinimtoxin A was used to get better diffusion.

Results

SUBMITTER: Stovner LJ 

PROVIDER: S-EPMC9109235 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature