Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.

ABSTRACT:

Objective

To conduct a comprehensive systematic review and meta-analysis to estimate the relationship between endocrine-disrupting chemicals (EDCs), including polychlorinated biphenyls (PCBs), poly-brominated diphenyl ethers (PBDEs), phthalates (PAEs), and per- and polyfluoroalkyl substances (PFAS) exposure and risk of gestational diabetes mellitus (GDM).

Methods

Relevant studies from their inception to November 2021 were identified by searching EMBASE, PubMed, and Web of Science. The cohort and case-control studies that reported effect size with 95% confidence intervals (CIs) of EDC exposure and GDM were selected. The heterogeneity among the included studies was quantified by I² statistic. Publication bias was evaluated through the Begg and Egger tests.

Result

SUBMITTER: Yan D 

PROVIDER: S-EPMC9109392 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature