Cisplatin and oleanolic acid Co-loaded pH-sensitive CaCO₃ nanoparticles for synergistic chemotherapy.

ABSTRACT: Despite being one of the most potent anticancer agents, cisplatin (CDDP) clinical usage is limited owing to the acquired resistance and severe adverse effects including nephrotoxicity. The current work has offered a unique approach by designing a pH-sensitive calcium carbonate drug delivery system for CDDP and oleanolic acid (OA) co-delivery, with an enhanced tumor efficacy and reduced unwanted effects. Micro emulsion method was employed to generate calcium carbonate cores (CDDP encapsulated) followed by lipid coating along with the OA loading resulting in the generation of lipid-coated cisplatin/oleanolic acid calcium carbonate nanoparticles (CDDP/OA-LCC NPs). In vitro biological assays confirmed the synergistic apoptotic effect of CDDP and OA against HepG2 cells. It was further ve

SUBMITTER: Khan MW 

PROVIDER: S-EPMC9109477 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature