Identification of key differential genes in intimal hyperplasia induced by left carotid artery ligation.

ABSTRACT:

Background

Intimal hyperplasia is a common pathological process of restenosis following angioplasty, atherosclerosis, pulmonary hypertension, vein graft stenosis, and other proliferative diseases. This study aims to screen for potential novel gene targets and mechanisms related to vascular intimal hyperplasia through an integrated microarray analysis of the Gene Expression Omnibus Database (GEO) database.

Material and methods

The gene expression profile of the GSE56143 dataset was downloaded from the Gene Expression Omnibus database. Functional enrichment analysis, protein-protein interaction (PPI) network analysis, and the transcription factor (TF)-target gene regulatory network were used to reveal the biological functions of differential genes (DEGs). Furthermore, the expr

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9109685 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature