Chromogranin A pathway: from pathogenic molecule to renal disease.

ABSTRACT:

Background

Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. It is elevated in plasma of patients with sympathetic over-activity and kidney dysfunction. Several CHGA polymorphisms are associated with hypertensive kidney disease. Previously, we unraveled the molecular mechanism by which CHGA expression is regulated in African Americans carrying a genetic variation associated with hypertensive chronic kidney disease (CKD).

Method

Experimental CKD mouse model were created by 5/6th nephrectomy (Npx) using wild-type and Chga-/- knockout mouse strains to delineate the role of CHGA in CKD.

Result

Wild-type-Npx mice expressing Chga developed exacerbated azotemia and fibrosis as compared with thei

SUBMITTER: Mir SA 

PROVIDER: S-EPMC9109708 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature