Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease.

ABSTRACT: Tau deposition is one of two hallmark features of biologically defined Alzheimer's disease (AD) and is more closely related to cognitive decline than amyloidosis. Further, not all amyloid-positive individuals develop tauopathy, resulting in wide heterogeneity in clinical outcomes across the population with AD. We hypothesized that a polygenic risk score (PRS) based on tau PET (tau PRS) would capture the aggregate inherited susceptibility/resistance architecture influencing tau accumulation, beyond solely the measurement of amyloid-β burden. Leveraging rich multimodal data from a population-based sample of older adults, we found that this novel tau PRS was a strong surrogate of tau PET deposition and captured a significant proportion of the variance in tau PET levels as compared with amyloi

SUBMITTER: Ramanan VK 

PROVIDER: S-EPMC9109940 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature