Sensitive identification of neoantigens and cognate TCRs in human solid tumors.

ABSTRACT: The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.

SUBMITTER: Arnaud M 

PROVIDER: S-EPMC9110298 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature