Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis.

ABSTRACT: Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To investigate the potential of stem cells in treating endometriosis, we examined the secondary morphology and molecular alterations in endometriosis-like lesions after the administration of adipose tissue-derived stem cells (ASCs) to an experimental murine model of endometriosis. The infused ASCs were found integrated in the endometriosis-like lesions. Accompanied by the suppression of stromal fibrosis and proliferation of endometriotic epithelial cells, the infusion of ASCs with stemness potential (early p

SUBMITTER: Hirakawa T 

PROVIDER: S-EPMC9110373 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature