A metamodel-based flexible insulin therapy for type 1 diabetes patients subjected to aerobic physical activity.

ABSTRACT: Patients with type 1 diabetes are subject to exogenous insulin injections, whether manually or through (semi)automated insulin pumps. Basic knowledge of the patient's characteristics and flexible insulin therapy (FIT) parameters are then needed. Specifically, artificial pancreas-like closed-loop insulin delivery systems are some of the most promising devices for substituting for endogenous insulin secretion in type 1 diabetes patients. However, these devices require self-reported information such as carbohydrates or physical activity from the patient, introducing potential miscalculations and delays that can have life-threatening consequences. Here, we display a metamodel for glucose-insulin dynamics that is subject to carbohydrate ingestion and aerobic physical activity. This metamodel in

SUBMITTER: Scharbarg E 

PROVIDER: S-EPMC9110411 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature