Stem Cells in Clinical Trials for Pelvic Floor Disorders: a Systematic Literature Review.

ABSTRACT: Pelvic floor disorders (PFDs) include a series of conditions that can be poorly tolerated, negatively affecting the quality of life. Current treatment options show unsatisfactory results and new ones are therefore needed. Stem cell (SC) therapy might be an alternative treatment strategy. This systematic review aims to define the state of art of SC therapy for PFDs in clinical trials, by systematically reviewing the available evidence. A systematic search strategy was conducted up to November 7, 2020, in PubMed, Scopus, Cochrane Library, and ISI Web of Science. Preclinical studies on animal models were not considered. Studies were included when the patients were affected by any PFDs and cells were isolated, cultured, and characterized as SC. The study protocol was registered in PROSPERO (CR

SUBMITTER: Manodoro S 

PROVIDER: S-EPMC9110489 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature